![]() ![]() ![]() ![]() “We wish to dedicate one specific chimpanzee derived serotype to one specific vaccine target” to avoid the possibility that antibodies induced by one vaccine vector might blunt the effect of another, he explained. “We’re working on different vaccines for Ebola, HIV, malaria, hepatitis C,” said Nicosia. The best ones, generating the biggest cellular immune responses, were chosen for making trial vaccines. They made safe forms of the viruses that were unable to replicate, and tested them for their immune potency in mice. Importantly, however, they generally don’t, so people haven’t built up antibodies to the viruses.Ĭollecting stool samples from zoos and animal facilities, Nicosia and his team isolated and characterized almost 30 different chimp adenovirus serotypes from some 1,000 stool samples. Because of people’s similarity to chimps, Nicosia reasoned, adenoviruses that can infect chimps can probably infect humans as well. Nicosia and his team found their alternative to human adenoviruses from a rather unpleasant source: chimp poop. “The preexisting immunity to human adenoviruses has. A second accompanying paper reports the successful clinical trial results for one such chimp virus-based vaccine for hepatitis C. According to their report, out today (January 4) in Science Translational Medicine, chimp adenoviruses avoid the problem of preexisting immunity that can dampen vaccine potency. Now, Nicosia and his colleagues believe they have found a solution-use chimpanzee adenoviruses instead. “The body has mounted an immune response, which stays for the rest of its life,” explained Alfredo Nicosia of Okairos in Rome, Italy. But there is one major problem-patients that have already been exposed to such adenoviruses naturally develop antibodies against them, which then neutralize the vaccine before it has a chance to deliver its package. Human adenoviruses have been proposed as vectors for antigens in vaccines because of their ability to induce strong immune responses in animal models. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |